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AMD patients can achieve anatomic benefit after switching to aflibercept

From the American Academy of Ophthalmology

This retrospective review assessed the effect of aflibercept 2.0 mg in wet AMD patients with persistent fluid on regular ranibizumab 0.5 mg and/or bevacizumab 1.25 mg. Subjects were 28 patients (28 eyes) who had an average of 20 regular ranibizumab/bevacizumab injections. At one month, 89 percent showed anatomic improvement and 18 percent were dry after a single aflibercept injection. Central subfoveal thickness improved from 295 to 272 microns (p<0.001) after one aflibercept injection, with gains maintained at six months. However, visual acuity did not improve. British Journal of Ophthalmology, August 2013

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