From the American Academy of Ophthalmology

This large retrospective study examined health records from Western Australian eye clinics to determine the risk of thromboembolic and gastrointestinal bleeding events in the 12 months after injections of bevacizumab or ranibizumab, compared with photodynamic therapy and untreated community controls. Though all adverse events were rare, anti-VEGF-treated patients were 2.3 times more likely to have a heart attack compared with controls. There was no difference in adverse events between bevacizumab and ranibizumab (1.6 and 2.1 events/100 persons, respectively). It’s unclear if the increased risk is associated with AMD itself or anti-VEGF treatment. Retina, June 2013